LI Cadherin 抗体 (AA 200-450)
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Quick Overview for LI Cadherin 抗体 (AA 200-450) (ABIN8093297)
抗原
See all LI Cadherin 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-450
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原理
- CDH17 Antibody / Cadherin 17
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免疫原
- A recombinant fragment (around amino acids 200-450) of human Cadherin 17 protein (CDH17) (exact sequence is proprietary) was used as the immunogen for the CDH17/Cadherin 17 antibody.
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亚型
- IgG2b, kappa
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anti-LI Cadherin (AA 242-418) antibody
适用: 人 IHC 宿主: 小鼠 Monoclonal 517M unconjugated
anti-LI Cadherin (AA 600-707) antibody适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 7D10E1 unconjugated
anti-LI Cadherin antibody适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated
anti-LI Cadherin antibody适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-LI Cadherin (AA 24-131) antibody适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1H3 unconjugated
anti-LI Cadherin antibody适用: 人 ELISA, FACS, BLI, Func, SPR 宿主: Human Monoclonal 10C12 unconjugated Recombinant Antibody
anti-LI Cadherin (AA 24-695) antibody适用: 人, 小鼠, 大鼠 IHC, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LI Cadherin (AA 242-418) antibody适用: 人 IHC, WB, FACS 宿主: 小鼠 Monoclonal CDH17-2618 unconjugated
anti-LI Cadherin (AA 67-351) antibody适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-LI Cadherin (AA 101-200) antibody适用: 人 WB, IHC (p), IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CDH17/Cadherin 17 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- CDH17/Cadherin 17 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- LI Cadherin
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别名
- CDH17
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背景
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CDH17 antibody targets Cadherin 17, also referred to as Liver-intestine cadherin, a calcium-dependent cell adhesion protein that belongs to the cadherin superfamily. Cadherin 17 is encoded by the CDH17 gene and is primarily localized to the cell membrane of epithelial cells within the gastrointestinal tract. Structurally, Cadherin 17 is a non-classical cadherin containing seven extracellular cadherin repeats and a short cytoplasmic tail that lacks a catenin-binding domain, distinguishing it from classical cadherins such as E-cadherin and N-cadherin.
Cadherin 17 plays an important role in epithelial organization and maintenance of tissue architecture in the intestine. CDH17 antibody is commonly used to examine adhesion-related processes in gastrointestinal epithelial cells, where Liver-intestine cadherin contributes to cell polarity and epithelial integrity. Unlike classical cadherins, Cadherin 17-mediated adhesion is less dependent on cytoskeletal anchoring, suggesting a more dynamic role in epithelial remodeling and turnover.
Expression of Cadherin 17 is highest in the small intestine and colon, with limited expression in most non-epithelial tissues. CDH17 antibody is therefore a useful reagent for studying gastrointestinal epithelial differentiation and lineage specificity. Liver-intestine cadherin expression patterns have been widely characterized in both normal intestinal mucosa and disease-associated contexts, making Cadherin 17 a well-established epithelial marker.
In cancer research, CDH17 antibody is frequently used as a diagnostic and classification marker for gastrointestinal-derived malignancies. Cadherin 17 expression is commonly retained in colorectal adenocarcinoma and other intestinal-type tumors, where it can assist in distinguishing gastrointestinal origin in metastatic disease. Altered expression of Liver-intestine cadherin has also been reported in tumor progression and invasion, supporting ongoing interest in Cadherin 17 biology.
This CDH17 antibody, clone CDH17/2613, is designed to recognize Cadherin 17 protein in research applications. Clone CDH17/2613 supports detection of membrane-associated CDH17 expression and is suitable for studies focused on epithelial adhesion, gastrointestinal biology, and tumor characterization. -
UniProt
- Q12864
抗原
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