CDH6 抗体 (AA 250-450)
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北京 101111
Quick Overview for CDH6 抗体 (AA 250-450) (ABIN8093275)
抗原
See all CDH6 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 250-450
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原理
- CDH6 Antibody / Cadherin 6 (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 250-450) of human Cadherin 6 protein (CDH6) (exact sequence is proprietary) was used as the immunogen for the CDH6/Cadherin 6 antibody.
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亚型
- IgG1, kappa
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anti-K-Cadherin (CDH6) (AA 281-380) antibody
CDH6 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 ELISA, FACS, BLI, Func, SPR 宿主: Human Monoclonal HKT288 unconjugated Recombinant Antibody
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人, 大鼠 WB, IHC, IHC (fro), ICC 宿主: 小鼠 Monoclonal 2B6 unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5060 unconjugated Recombinant Antibody
anti-K-Cadherin (CDH6) (AA 513-612) antibodyCDH6 适用: 人 WB, RNAi 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-K-Cadherin (CDH6) (AA 1-250) antibodyCDH6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) (AA 153-424) antibodyCDH6 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) (AA 665-695), (C-Term) antibodyCDH6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CDH6/Cadherin 6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- CDH6/Cadherin 6 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CDH6 (K-Cadherin (CDH6))
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别名
- CDH6
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背景
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CDH6 antibody targets Cadherin 6, also known as K-Cadherin, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6 is a single-pass transmembrane glycoprotein predominantly localized to the plasma membrane at adherens junctions, where it mediates homophilic adhesion between neighboring cells. CDH6 expression is most prominent in renal epithelium, nervous system tissues, and select epithelial compartments, reflecting its role in tissue organization and morphogenesis.
Functionally, Cadherin 6 contributes to epithelial cohesion and structural integrity by linking adjacent cells through calcium-dependent interactions and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 supports stable cell-cell adhesion required for proper epithelial architecture and differentiation. Through these adhesive functions, K-Cadherin influences cell polarity, migration, and tissue patterning during development.
At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains responsible for calcium binding and adhesive specificity, a transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and related adaptor proteins. These structural features integrate extracellular adhesion with intracellular signaling pathways. CDH6 antibody reagents are therefore valuable for studying adherens junction biology, epithelial development, and regulation of cell-cell contacts. Clone CDH6/9347 is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.
From a biological and disease relevance perspective, altered Cadherin 6 expression has been reported in several cancers, including renal, ovarian, and thyroid carcinomas, where changes in CDH6 levels may be associated with tumor progression and invasive behavior. Cadherin 6 is also investigated in developmental biology due to its regulated expression during organogenesis. Clone CDH6/9347 provides a reliable reagent for examining Cadherin 6 expression in studies of epithelial differentiation, cancer biology, and cell adhesion dynamics.
Developmentally, CDH6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes. CDH6 antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, development, and translational research. -
UniProt
- P55285
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途径
- Cell-Cell Junction Organization
抗原
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