Recombinant ISL1 抗体
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北京 101111
Quick Overview for Recombinant ISL1 抗体 (ABIN8093272)
抗原
See all ISL1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ISL1 Antibody / Islet 1
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Islet 1 protein was used as the immunogen for the Islet 1 antibody.
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亚型
- IgG
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anti-ISL LIM Homeobox 1 (ISL1) (AA 63-159) antibody
ISL1 适用: 人 WB, RNAi 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-ISL LIM Homeobox 1 (ISL1) (AA 63-159) antibodyISL1 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-ISL LIM Homeobox 1 (ISL1) antibodyISL1 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 1H9 unconjugated
anti-ISL LIM Homeobox 1 (ISL1) antibodyMicroarray verified ISL1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB381223 unconjugated
anti-ISL LIM Homeobox 1 (ISL1) antibodyISL1 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1A1 unconjugated Recombinant Antibody
anti-ISL LIM Homeobox 1 (ISL1) antibodyISL1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6115 unconjugated Recombinant Antibody
anti-ISL LIM Homeobox 1 (ISL1) antibodyISL1 适用: 人 WB, ICC, IF, IHC (p), IHC (fro), IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-ISL LIM Homeobox 1 (ISL1) antibodyISL1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6450 unconjugated Recombinant Antibody
anti-ISL LIM Homeobox 1 (ISL1) (AA 1-346) antibodyISL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ISL LIM Homeobox 1 (ISL1) (AA 63-159) antibodyISL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A7 unconjugated
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应用备注
- Optimal dilution of the Islet 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Islet 1 antibody at -20oC.
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- ISL1 (ISL LIM Homeobox 1 (ISL1))
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别名
- ISL1
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背景
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Islet 1 antibody targets Islet 1 (ISL1), a LIM homeobox transcription factor that plays a critical role in embryonic development, cell fate specification, and tissue differentiation. ISL1 localizes predominantly to the nucleus, where it regulates gene expression programs required for the development of multiple organ systems. It is a member of the LIM homeodomain family of transcription factors, characterized by two LIM domains that mediate protein-protein interactions and a homeobox DNA-binding domain that enables sequence-specific transcriptional control.
Functionally, ISL1 is essential for the development of pancreatic endocrine cells, motor neurons, and cardiac progenitor populations. In the pancreas, ISL1 is required for differentiation and maintenance of insulin-producing beta cells and other endocrine lineages, making it a widely used marker for pancreatic progenitors and mature endocrine cells. In the nervous system, ISL1 is involved in motor neuron identity and axonal pathfinding, while in the heart it contributes to the specification and proliferation of second heart field progenitors. An Islet 1 antibody supports studies examining developmental gene regulation and lineage specification.
ISL1 expression is tightly regulated in a spatially and temporal manner during development and is largely restricted in adult tissues to specific cell populations. Its nuclear localization and lineage-specific expression pattern make ISL1 a valuable marker in developmental biology and stem cell research. Changes in ISL1 expression can influence differentiation trajectories and tissue organization, reflecting its central role in coordinating complex developmental programs across organ systems.
From a biological and disease-relevance perspective, ISL1 has been studied extensively in the context of congenital heart defects, pancreatic dysfunction, and neurodevelopmental disorders. In cancer research, ISL1 expression has been reported in certain neuroendocrine tumors, where it is used as a diagnostic marker reflecting lineage origin. Understanding ISL1 expression and regulation provides insight into mechanisms that govern cell identity and developmental plasticity.
At the molecular level, ISL1 is encoded by the ISL1 gene and produces a protein of approximately 349 amino acids. The LIM domains facilitate assembly of transcriptional complexes, while the homeodomain mediates DNA binding and transcriptional regulation. ISL1 activity is modulated through interactions with cofactors and developmental signaling pathways. An Islet 1 antibody supports research applications focused on developmental biology, transcriptional regulation, and lineage-specific marker analysis, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- P61371
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途径
- Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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