HSD17B13 抗体 (AA 1-200)
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Quick Overview for HSD17B13 抗体 (AA 1-200) (ABIN8093251)
抗原
See all HSD17B13 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- HSD17B13 Antibody / Hydroxysteroid 17 beta dehydrogenase 13 (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1-200) of human HSD17B13 protein (exact sequence is proprietary) was used as the immunogen for the Hepatic lipid droplet protein antibody.
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亚型
- IgG2b, kappa
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13) (AA 20-300) antibody
HSD17B13 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13) antibodyHSD17B13 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13) (AA 81-110), (N-Term) antibodyHSD17B13 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB27107 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13) antibodyHSD17B13 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13) (AA 91-140) antibodyHSD17B13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Hepatic lipid droplet protein antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Hepatic lipid droplet protein antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))
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别名
- HSD17B13
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背景
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Hepatic lipid droplet protein antibody recognizes 17 beta hydroxysteroid dehydrogenase type 13, a liver-enriched enzyme encoded by the HSD17B13 gene that localizes predominantly to the cytoplasm and lipid droplet-associated compartments of hepatocytes. This protein belongs to the short-chain dehydrogenase reductase family and is strongly linked to hepatic lipid metabolism. Because of its restricted tissue distribution and functional association with lipid droplets, a hepatic lipid droplet protein antibody is widely used in studies of liver biology, metabolic regulation, and fatty liver disease.
17 beta hydroxysteroid dehydrogenase type 13 is structurally related to other hydroxysteroid dehydrogenases but displays a distinct expression pattern that is largely confined to liver tissue. In hepatocytes, the protein associates with lipid droplets, positioning it at the interface between lipid storage and metabolic processing. Hepatic lipid droplet protein antibody-based detection enables visualization and analysis of this compartmentalized expression pattern, supporting research into lipid droplet dynamics and hepatocellular metabolism.
Genetic and functional studies have identified 17 beta hydroxysteroid dehydrogenase type 13 as a key modifier of liver disease susceptibility. Loss-of-function variants in the HSD17B13 gene are associated with reduced risk of non-alcoholic fatty liver disease, steatohepatitis, and progression to advanced liver fibrosis. Conversely, altered expression of this hepatic lipid droplet protein has been reported in fatty liver disease and hepatocellular carcinoma. Use of a hepatic lipid droplet protein antibody allows researchers to examine protein-level changes associated with disease risk, progression, and tumor biology.
As a member of the hydroxysteroid dehydrogenase family, 17 beta hydroxysteroid dehydrogenase type 13 contains a conserved enzymatic domain characteristic of short-chain dehydrogenase reductases. Although its precise endogenous substrates remain an area of active investigation, its lipid droplet localization suggests a role in regulating lipid-associated redox reactions or signaling pathways within hepatocytes. A hepatic lipid droplet protein antibody therefore provides a valuable tool for exploring enzyme localization, metabolic context, and functional interactions in liver cells.
Expression of 17 beta hydroxysteroid dehydrogenase type 13 is minimal or absent in most extrahepatic tissues, making it a useful marker of hepatocyte identity and liver-specific metabolic states. Antibody-based detection of this hepatic lipid droplet protein is particularly useful in studies of hepatic differentiation, metabolic remodeling, and liver pathology. Clone HSD17B13/13107 is designed to recognize 17 beta hydroxysteroid dehydrogenase type 13 and supports detection of this target in relevant research applications. NSJ Bioreagents offers this hepatic lipid droplet protein antibody to support investigations into liver metabolism, fatty liver disease biology, and hepatocellular function. -
UniProt
- Q7Z5P4
抗原
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