HNF1B 抗体 (AA 1-200)
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北京 101111
Quick Overview for HNF1B 抗体 (AA 1-200) (ABIN8093247)
抗原
See all HNF1B 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- HNF1B Antibody / Transcription factor HNF1 beta (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1-200) of human HNF1B protein (exact sequence is proprietary) was used as the immunogen for the TCF2/HNF1B antibody.
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亚型
- IgG2b, kappa
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anti-HNF1 Homeobox B (HNF1B) (AA 29-118) antibody
HNF1B 适用: 人 WB 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-HNF1 Homeobox B (HNF1B) (AA 29-118) antibodyHNF1B 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-HNF1 Homeobox B (HNF1B) (N-Term) antibodyHNF1B 适用: 人, 大鼠, 小鼠, 斑马鱼, 犬, Cow, 马, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (AA 159-300) antibodyHNF1B 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (AA 1-557) antibodyHNF1B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (Internal Region) antibodyVerified HNF1B 适用: 人, 小鼠 WB, ELISA, ICC 宿主: 山羊 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (Internal Region) antibodyHNF1B 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (C-Term) antibodyHNF1B 适用: 人, 大鼠, 小鼠, 犬, Cow, 马, 豚鼠, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox B (HNF1B) (AA 212-245) antibodyHNF1B 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB48027 unconjugated
anti-HNF1 Homeobox B (HNF1B) (AA 498-529), (C-Term) antibodyHNF1B 适用: 人 WB 宿主: 兔 Polyclonal RB19184 unconjugated
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应用备注
- Optimal dilution of the TCF2/HNF1B antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- TCF2/HNF1B antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- HNF1B (HNF1 Homeobox B (HNF1B))
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别名
- HNF1B
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背景
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TCF2 antibody, also known as Hepatocyte nuclear factor 1 beta antibody, recognizes a homeodomain-containing transcription factor encoded by the HNF1B gene. This protein is commonly referred to as HNF1 beta and was historically described as TCF2 in early genetic studies. HNF1B is a nuclear transcription factor that regulates gene expression during embryonic development and adult tissue homeostasis, particularly in liver, kidney, pancreas, and genitourinary epithelium.
HNF1B belongs to the homeodomain-containing transcription factor family and functions as either a homodimer or heterodimer with HNF1A. It binds specific DNA promoter sequences and regulates genes involved in epithelial differentiation, glucose metabolism, and organ morphogenesis. The protein contains a dimerization domain, a POU-specific DNA binding domain, and a transactivation domain that mediates transcriptional regulation of downstream targets.
During development, HNF1B plays a critical role in renal tubulogenesis, pancreatic organogenesis, and hepatobiliary differentiation. It is highly expressed in renal tubular epithelial cells, bile ducts, pancreatic ductal cells, and certain epithelial-derived tissues. Disruption of HNF1B expression alters nephron segmentation and epithelial polarity, highlighting its role in tissue architecture and functional maturation.
Clinically, mutations in HNF1B are associated with Renal cysts and diabetes syndrome, also known as MODY5, as well as congenital abnormalities of the kidney and urinary tract. Loss or altered expression has also been described in subsets of renal cell carcinoma and gynecologic malignancies. Because of its consistent nuclear localization and epithelial lineage specificity, TCF2 antibody is widely used for evaluating HNF1B expression in developmental biology and oncology research.
In normal tissues, HNF1B localizes predominantly to the nucleus, consistent with its transcription factor function. Altered nuclear expression patterns may reflect dysregulation of epithelial differentiation programs. A TCF2 antibody can be used in research applications to detect HNF1B protein expression in relevant experimental systems. -
UniProt
- P35680
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途径
- Hormone Transport, Stem Cell Maintenance, Tube Formation
抗原
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