Recombinant HTATSF1 抗体
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Quick Overview for Recombinant HTATSF1 抗体 (ABIN8093236)
抗原
See all HTATSF1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HTATSF1 Antibody / HIV Tat-specific factor 1
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纯化方法
- Purified
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免疫原
- A synthesized peptide derived from human HIV Tat-specific factor 1 protein was used as the immunogen for the HIV Tat-specific factor 1 antibody.
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亚型
- IgG
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anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 1-270) antibody
HTATSF1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (C-Term) antibodyHTATSF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) antibodyHTATSF1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) antibodyHTATSF1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5935 unconjugated Recombinant Antibody
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 1-30), (N-Term) antibodyHTATSF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB18094 unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (Internal Region) antibodyVerified HTATSF1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 375-425) antibodyHTATSF1 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 612-661) antibodyHTATSF1 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 608-657) antibodyHTATSF1 适用: 人, 犬, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-HIV-1 Tat Specific Factor 1 (HTATSF1) (AA 375-425) antibodyHTATSF1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HIV Tat-specific factor 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HIV Tat-specific factor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HTATSF1 (HIV-1 Tat Specific Factor 1 (HTATSF1))
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别名
- HTATSF1
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背景
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HIV Tat-specific factor 1 antibody targets HIV Tat-specific factor 1, encoded by the HTATSF1 gene on chromosome 17q21.31. HIV Tat-specific factor 1 is a nuclear regulatory protein that functions at the intersection of transcription elongation and RNA processing. Although first identified for its role in supporting HIV-1 Tat-mediated transcription, HIV Tat-specific factor 1 is now recognized as a broader host factor that contributes to efficient gene expression in mammalian cells.
Functionally, HIV Tat-specific factor 1 participates in regulation of RNA polymerase II elongation rather than transcription initiation. It associates with elongating transcription complexes and supports productive transcript synthesis across actively transcribed genes. In parallel, HIV Tat-specific factor 1 facilitates coordination between transcriptional elongation and RNA processing events, allowing efficient coupling of nascent RNA synthesis with downstream maturation steps. A HIV Tat-specific factor 1 antibody supports studies focused on transcriptional elongation dynamics and RNA metabolism.
HIV Tat-specific factor 1 localizes predominantly to the nucleus, where it interacts with components of the transcription and splicing machinery. The protein contains arginine-serine-rich regions and additional interaction motifs characteristic of RNA regulatory factors, enabling binding to RNA and protein partners within elongation and spliceosomal complexes. Alternative splicing of HTATSF1 transcripts may generate isoforms that modulate these regulatory activities in a context-dependent manner.
From a biological and disease-relevance perspective, accurate regulation of transcription elongation and RNA processing is essential for cellular homeostasis. Dysregulated activity of HIV Tat-specific factor 1 has been investigated in cancer, where aberrant transcriptional control contributes to altered gene expression programs. In viral infection models, HIV Tat-specific factor 1 remains relevant due to its ability to enhance Tat-dependent transcription, illustrating how host transcription factors can be co-opted to support viral replication.
At the molecular level, HIV Tat-specific factor 1 functions as a regulatory protein rather than an enzyme, acting through dynamic protein-protein and protein-RNA interactions. Post-translational regulation and complex assembly state can influence its functional behavior and apparent migration in biochemical assays without altering the primary amino acid sequence. HIV Tat-specific factor 1 antibody reagents support research applications focused on transcription elongation, RNA processing, and host-virus interactions, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- O43719
抗原
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