Recombinant FOLR1 抗体
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北京 101111
Quick Overview for Recombinant FOLR1 抗体 (ABIN8093188)
抗原
See all FOLR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- FOLR1 Antibody / Folate receptor 1 (azide and preservative free)
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免疫原
- Recombinant human FOLR1 protein was used as the immuongen for the FOLR1/Folate receptor 1 antibody.
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亚型
- IgG2a, kappa
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anti-Folate Receptor 1 (Adult) (FOLR1) (AA 41-227) antibody
FOLR1 适用: 人 IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2G5C12 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) antibodyFOLR1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-93) antibodyFOLR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-234) antibodyFOLR1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (Middle Region) antibodyFOLR1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 41-227) antibodyFOLR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3G12B7 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 33-68), (N-Term) antibodyFOLR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB28535 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 179-228) antibodyFOLR1 适用: 人, 小鼠, 大鼠, Hamster, 犬, 马, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (Internal Region) antibodyFOLR1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-234) antibodyFOLR1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FOLR1/Folate receptor 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- FOLR1/Folate receptor 1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
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别名
- FOLR1
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背景
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FOLR1 antibody is used to study Folate receptor 1, a high-affinity folate binding protein that plays a central role in cellular folate uptake and utilization. Folate receptor 1 is encoded by the FOLR1 gene and belongs to a small family of folate receptors that bind folic acid and related folates with nanomolar affinity. By concentrating folate at the cell surface, Folate receptor 1 supports metabolic pathways essential for DNA synthesis, methylation reactions, and cellular growth.
Folate receptor 1 is a glycosylphosphatidylinositol-anchored protein that localizes to the plasma membrane, where it mediates folate internalization through receptor-dependent endocytic mechanisms. This mode of transport is distinct from reduced folate carriers and proton-coupled folate transporters, allowing Folate receptor 1 to function efficiently in specific tissue environments. Studies using FOLR1 antibody have helped define the biochemical properties and trafficking behavior of this receptor within folate transport networks.
Expression of Folate receptor 1 is tightly regulated and typically restricted to select epithelial tissues, including placenta and kidney, reflecting tissue-specific folate requirements. In polarized epithelial cells, Folate receptor 1 often exhibits apical membrane localization, consistent with its role in directional nutrient uptake. Detection of Folate receptor 1 using a FOLR1 antibody supports investigation of epithelial organization, membrane specialization, and nutrient transport dynamics.
In disease-related research, altered expression of Folate receptor 1 has been examined in epithelial malignancies and conditions associated with dysregulated folate metabolism. Increased FOLR1 expression is thought to reflect heightened folate demand and metabolic adaptation rather than lineage alone. As a result, FOLR1 antibody is widely applied in studies exploring metabolic reprogramming, epithelial tumor biology, and folate-dependent cellular processes.
FOLR1 antibody (clone rFOLR1/13324) is designed to detect Folate receptor 1 in research applications. Analysis of FOLR1 expression enables evaluation of folate binding capacity, membrane-associated receptor distribution, and tissue-specific metabolic regulation. Overall, Folate receptor 1 remains a key component of folate biology and an important target for studies of epithelial physiology and disease-associated metabolic change. -
UniProt
- P15328
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途径
- Dicarboxylic Acid Transport
抗原
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