Recombinant Filaggrin 抗体 (N-Term)
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Quick Overview for Recombinant Filaggrin 抗体 (N-Term) (ABIN8093184)
抗原
See all Filaggrin (FLG) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- N-Term
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原理
- Filaggrin Antibody (azide and preservative free)
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免疫原
- Prokaryotic recombinant protein corresponding to a portion of the N-terminus of the human filaggrin molecule was used as the immunogen for the FLG / Filaggrin antibody.
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亚型
- IgG1, kappa
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anti-Filaggrin (FLG) (AA 198-288) antibody
FLG 适用: 人 IHC 宿主: 小鼠 Monoclonal FLG-1561 unconjugated
anti-Filaggrin (FLG) (AA 998-1104) antibodyFLG 适用: 人 IHC 宿主: 小鼠 Monoclonal FLG-1563 unconjugated
anti-Filaggrin (FLG) (C-Term) antibodyFLG 适用: 人, 小鼠, 大鼠 IHC, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Filaggrin (FLG) (AA 119-336) antibodyFLG 适用: 小鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Filaggrin (FLG) (AA 198-288) antibodyFLG 适用: 人 IHC 宿主: 兔 Monoclonal FLG-1957R unconjugated Recombinant Antibody
anti-Filaggrin (FLG) (AA 198-288) antibodyFLG 适用: 人 IHC 宿主: 小鼠 Monoclonal rFLG-1561 unconjugated Recombinant Antibody
anti-Filaggrin (FLG) antibodyFLG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Filaggrin (FLG) (AA 3838-4061) antibodyFLG 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Filaggrin (FLG) (AA 1-261) antibodyFLG 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Filaggrin (FLG) (AA 3905-4031) antibodyFLG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Optimal dilution of the FLG / Filaggrin antibody should be determined by the researcher.
2. This FLG/Filaggrin antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- FLG / Filaggrin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- Filaggrin (FLG)
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别名
- Filaggrin
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背景
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FLG antibody targets Filaggrin, a high molecular weight structural protein encoded by the FLG gene that plays a central role in epidermal differentiation and skin barrier formation. Filaggrin is synthesized as a large profilaggrin precursor that accumulates in keratohyalin granules within the granular layer of stratified squamous epithelium. During terminal keratinocyte differentiation, profilaggrin undergoes proteolytic processing to generate multiple filaggrin monomers that bind keratin intermediate filaments in the cytoplasm, promoting filament aggregation and cellular flattening characteristic of the stratum corneum.
Beyond its structural function, Filaggrin contributes to epidermal barrier integrity through further degradation into hygroscopic amino acids and derivatives collectively known as natural moisturizing factors. These breakdown products regulate skin hydration, surface pH , and antimicrobial defense. Reduced or absent filaggrin expression compromises barrier function and increases transepidermal water loss, underscoring the importance of Filaggrin in maintaining normal skin physiology.
FLG antibody, also referred to as filaggrin antibody, is widely used to study epidermal differentiation, keratinocyte maturation, and skin barrier biology. Filaggrin expression is tightly restricted to differentiating keratinocytes and is most prominent in the granular layer of the epidermis, making it a useful marker for epithelial lineage characterization. Altered filaggrin expression has been strongly associated with inflammatory and hyperproliferative skin disorders, and loss-of-function FLG mutations are a major genetic risk factor for ichthyosis vulgaris and atopic dermatitis.
Clone r15C10 is designed to recognize Filaggrin and supports detection of filaggrin expression and localization in research applications. Use of an FLG antibody enables investigation of epidermal differentiation status, barrier defects, and disease-associated changes in keratinocyte biology.
Explore our < a href=../tds/filaggrin-antibody-flg1563-v3840>Filaggrin Antibody / Epidermal Differentiation Marker page for additional validation data and research applications involving keratinocyte maturation, epithelial barrier biology, and dermatopathology-associated signaling pathways. -
UniProt
- P20930
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途径
- Sensory Perception of Sound, Stem Cell Maintenance
抗原
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