ERG 抗体 (AA 1-300)
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北京 101111
Quick Overview for ERG 抗体 (AA 1-300) (ABIN8093156)
抗原
See all ERG 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-300
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原理
- ERG Antibody / ETS transcription factor ERG (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1-300) of human ERG (exact sequence is proprietary) was used as the immunogen for the ERG/Prostate cancer ERG antibody.
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亚型
- IgG1, kappa
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anti-ERG, ETS transcription factor (ERG) antibody
ERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4H7 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyVerified ERG 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 5F12 unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-160) antibodyERG 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-486) antibodyERG 适用: 人 IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ERG/Prostate cancer ERG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- ERG/Prostate cancer ERG antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- ERG (ERG, ETS transcription factor (ERG))
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别名
- ERG
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背景
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ERG antibody targets ETS related gene, a nuclear transcription factor encoded by the ERG gene that is aberrantly expressed in a large subset of prostate cancers. In prostate carcinoma, ERG expression most commonly arises from gene rearrangements that place ERG under the control of androgen-responsive promoters, leading to inappropriate transcriptional activation in prostate epithelial cells. As a result, ERG antibody detection is widely used in research settings to study prostate cancer-associated transcriptional reprogramming.
In normal tissues, ERG expression is largely restricted to vascular endothelial cells and select hematopoietic populations. In contrast, nuclear ERG expression in prostate epithelial cells is considered abnormal and reflects oncogenic activation rather than normal differentiation. This distinction makes ERG antibody reagents particularly valuable for examining prostate tumor biology and for distinguishing malignant epithelial cells from surrounding benign glands in tissue-based studies.
Functionally, ERG acts as a transcriptional regulator that influences genes involved in cell migration, invasion, and survival. In prostate cancer models, ERG overexpression has been associated with altered chromatin organization and cooperation with androgen receptor signaling pathways, contributing to tumor initiation and progression. ERG antibody tools support investigations into how transcription factor dysregulation reshapes gene expression programs in prostate carcinoma.
ERG expression in prostate cancer is strongly associated with specific molecular subtypes and is frequently evaluated in the context of tumor classification and disease stratification research. Nuclear ERG positivity has been correlated with distinct histopathologic features and molecular profiles, making ERG antibody-based detection relevant for studies of prostate cancer heterogeneity and progression mechanisms.
Clone ERG1/12589 is designed to recognize ERG in research applications. ERG antibody reagents are suitable for detecting nuclear ERG expression in prostate cancer tissue samples, supporting studies focused on oncogenic transcription factor activity, prostate tumor biology, and disease-associated alterations in gene regulation. -
UniProt
- P11308
抗原
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