ERG 抗体 (AA 1-300)
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北京 101111
Quick Overview for ERG 抗体 (AA 1-300) (ABIN8093153)
抗原
See all ERG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-300
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原理
- ERG Antibody / ETS related gene
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免疫原
- A recombinant fragment (around amino acids 1-300) of human ERG (exact sequence is proprietary) was used as the immunogen for the ERG/ETS related gene antibody.
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亚型
- IgG1, kappa
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anti-ERG, ETS transcription factor (ERG) antibody
ERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4H7 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyVerified ERG 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 5F12 unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-160) antibodyERG 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-486) antibodyERG 适用: 人 IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ERG/ETS related gene antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- ERG/ETS related gene antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- ERG (ERG, ETS transcription factor (ERG))
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别名
- ERG
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背景
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ERG antibody targets ETS related gene, a nuclear transcription factor encoded by the ERG gene and a member of the ETS family of transcriptional regulators. ERG plays a critical role in gene expression programs that control endothelial cell differentiation, vascular development, and hematopoietic lineage specification. Through sequence-specific DNA binding, ERG regulates transcriptional networks essential for cell identity and tissue homeostasis.
ERG is predominantly localized in the nucleus and is highly expressed in vascular endothelial cells and cells of hematopoietic origin. Its expression pattern makes ERG antibody detection particularly useful for identifying endothelial cells and assessing vascular differentiation in tissue samples. In addition, ERG expression is observed in subsets of hematologic cells, reflecting its role in blood cell development and maintenance.
Functionally, ERG regulates genes involved in cell survival, migration, and differentiation. In endothelial cells, ERG supports vascular stability and angiogenic capacity by modulating transcriptional responses to developmental and environmental cues. ERG antibody reagents therefore support investigations into transcriptional control mechanisms underlying vascular biology and endothelial cell function.
Alterations in ERG expression are associated with several disease contexts. ERG gene rearrangements and overexpression are well documented in prostate cancer, most commonly through fusion with androgen-regulated promoters, leading to aberrant transcriptional activity. ERG expression has also been implicated in certain leukemias and vascular tumors, where dysregulated transcription contributes to disease progression. These associations highlight the relevance of ERG antibody-based detection in cancer research and hematopathology studies.
Clone ERG1/12590 is designed to recognize ETS related gene in research applications. ERG antibody reagents are suitable for detecting nuclear ERG expression in endothelial and hematopoietic cells, supporting studies focused on vascular biology, transcriptional regulation, and disease-associated alterations in ETS family signaling. -
UniProt
- P11308
抗原
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