EGFL7 抗体 (AA 1-200)
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北京 101111
Quick Overview for EGFL7 抗体 (AA 1-200) (ABIN8093142)
抗原
See all EGFL7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- EGFL7 Antibody / EGF-like domain-containing protein 7
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免疫原
- A recombinant fragment (around amino acids 1-200) of human EGFL7 protein (exact sequence is proprietary) was used as the immunogen for the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody.
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亚型
- IgG1, kappa
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anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 1-273) antibody
EGFL7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 22-275) antibodyEGFL7 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 24-273) antibodyEGFL7 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 30-80) antibodyEGFL7 适用: 小鼠 IF, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 24-273) antibodyEGFL7 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3G1 unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (Internal Region) antibodyVerified EGFL7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 24-100) antibodyEGFL7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 73-198) antibodyEGFL7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 1-273) antibodyEGFL7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-EGF-Like-Domain, Multiple 7 (EGFL7) (AA 24-273) antibodyEGFL7 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Epidermal Growth Factor-Like Protein 7/EGFL7 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))
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别名
- EGFL7
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背景
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Epidermal Growth Factor-Like Protein 7 antibody, also known as EGFL7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as EGF-like domain-containing protein 7 and Vascular endothelial statin. Epidermal Growth Factor-Like Protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it incorporates into the vascular basement membrane and contributes to vascular integrity and remodeling. EGFL7 expression is particularly elevated during embryonic angiogenesis and in tissues undergoing active vascular remodeling.
Epidermal Growth Factor-Like Protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubule formation. It plays a key role in vascular lumen formation and stabilization of endothelial architecture. EGFL7 antibody is widely used in studies of angiogenesis, tumor-associated neovascularization, and vascular development. The protein has also been shown to modulate Notch signaling in endothelial cells, influencing vascular patterning and differentiation during development.
Structurally, Epidermal Growth Factor-Like Protein 7 contains multiple epidermal growth factor-like repeats that mediate interactions with integrins and other extracellular matrix components. Through these domains, EGFL7 supports endothelial cell-matrix communication and maintains vascular stability. Its expression is developmentally regulated, with high levels in embryonic vasculature and more restricted expression in adult tissues except during repair, inflammation, or tumor angiogenesis.
Dysregulated EGFL7 expression has been associated with cancer progression and metastasis. Increased EGFL7 levels are observed in colorectal, breast, and hepatocellular carcinomas, where enhanced angiogenesis supports tumor growth and dissemination. Because EGFL7 is largely endothelial-specific, it serves as a valuable marker for studying tumor vasculature and vascular remodeling processes. Its extracellular localization also makes it of interest in therapeutic strategies targeting angiogenesis.
Epidermal Growth Factor-Like Protein 7 antibody supports research in vascular biology, angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9499 recognizes EGFL7 and is suitable for detecting Epidermal Growth Factor-Like Protein 7 expression in relevant research applications. -
UniProt
- Q9UHF1
抗原
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