Recombinant CD39 抗体
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北京 101111
Quick Overview for Recombinant CD39 抗体 (ABIN8093139)
抗原
See all CD39 (ENTPD1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- CD39 Antibody / ENTPD1 (azide and preservative free)
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免疫原
- Prokaryotic recombinant protein corresponding to a portion of the external domain of the CD39 molecule was used as the immunogen for the ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody.
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亚型
- IgG2a, kappa
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anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 1-180) antibody
ENTPD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 79-411) antibodyENTPD1 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 300-350) antibodyENTPD1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR285L unconjugated Recombinant Antibody
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6H12F9 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8E9F2 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 398-411), (Extracellular Loop) antibodyENTPD1 适用: 人 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 316-474) antibodyENTPD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 241-486) antibodyENTPD1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Optimal dilution of the ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody should be determined by the researcher.
2. This ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
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别名
- CD39
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背景
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ENTPD1 Antibody recognizes CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1, a plasma membrane ectoenzyme that regulates extracellular nucleotide signaling. Encoded by the ENTPD1 gene, CD39 hydrolyzes extracellular ATP and ADP to AMP, thereby modulating purinergic signaling pathways involved in inflammation, thrombosis, and immune regulation. ENTPD1 Antibody is suitable for detecting CD39 expression in research applications focused on immune homeostasis and tumor microenvironment biology.
ENTPD1 antibody, also referred to as CD39 antibody and NTPDase1 antibody in the literature, targets a glycosylated transmembrane protein expressed on endothelial cells, regulatory T cells, B cells, monocytes, macrophages, and selected epithelial populations. By limiting extracellular ATP and cooperating with CD73 to generate adenosine, CD39 contributes to immunosuppressive signaling pathways that regulate lymphocyte activation and maintain vascular homeostasis. Increased CD39 expression has been associated with immune tolerance and tumor-associated immune suppression.
The ENTPD1 gene is located on chromosome 10q24.1 and encodes a protein containing two transmembrane regions and a large extracellular catalytic domain with conserved apyrase motifs required for nucleotide hydrolysis. CD39 localizes predominantly to the plasma membrane and demonstrates membranous staining in endothelial and immune cell populations in tissue sections. Expression is particularly prominent in lymphoid tissues such as tonsil and lymph node, as well as in vascular endothelium and placenta.
Dysregulation of ENTPD1 expression has been implicated in cancer progression, chronic inflammatory disease, thrombosis, and cardiovascular disorders. Clone r22A9 is a recombinant mouse monoclonal antibody developed to recognize ENTPD1 / CD39 in experimental systems. -
UniProt
- P49961
抗原
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