Recombinant D-Dimer 抗体
The 兔 单克隆 anti-D-Dimer antibody is suitable to detect D-Dimer in samples from 人. It has been validated for WB.
产品编号 ABIN8093123
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant D-Dimer 抗体 (ABIN8093123)
抗原
See all D-Dimer 抗体
D-Dimer
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
单克隆
标记
This D-Dimer antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
FGG-13043R
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原理
- D-dimer Antibody / Cross-linked fibrin fragment
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免疫原
- Recombinant human FGA protein (exact sequence is proprietary) was used as the immuongen for the D-dimer antibody.
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亚型
- IgG, kappa
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anti-D-Dimer antibody
适用: 人 ELISA, Aggl, LA 宿主: 兔 Chimeric 3B6 unconjugated Recombinant Antibody
anti-D-Dimer antibody适用: 人 ELISA, WB, PrA 宿主: 小鼠 Monoclonal DD1 unconjugated
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应用备注
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1. Optimal dilution of the D-dimer antibody should be determined by the researcher.
2. This D-dimer antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- D-dimer antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- D-Dimer
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背景
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D-dimer antibody targets a neoantigenic epitope present on the cross-linked fibrin fragment known as D-dimer, a specific fibrin degradation product generated during active coagulation and fibrinolysis. D-dimer is formed only after fibrinogen is converted to fibrin by thrombin, fibrin strands are covalently cross-linked by factor XIIIa, and the stabilized clot is subsequently cleaved by plasmin. This multistep requirement makes D-dimer a highly specific molecular marker of clot formation and breakdown rather than a marker of native fibrinogen or unprocessed fibrin.
D-dimer is derived primarily from the gamma chain region of fibrinogen (FGG) following cross-linking and proteolytic cleavage, creating a unique conformational epitope that is absent in intact fibrinogen, non-cross-linked fibrin, or individual fibrinogen chains. Antibodies directed against this neoepitope selectively recognize cross-linked fibrin degradation products, providing high specificity for biologically relevant clot turnover. As a result, D-dimer antibody reagents are fundamentally different from antibodies raised against fibrinogen alpha, beta, or gamma chains, which detect native circulating proteins rather than processed clot fragments.
The biological significance of D-dimer lies in its role as a direct indicator of ongoing or recent coagulation activity. Elevated D-dimer levels reflect activation of both the coagulation cascade and the fibrinolytic system, making D-dimer a widely used biomarker in thrombosis research and clinical diagnostics. D-dimer antibody tools are extensively applied in studies of venous thromboembolism, disseminated intravascular coagulation, cardiovascular disease, inflammation-associated coagulopathy, cancer-associated thrombosis, and sepsis-related clotting abnormalities.
In tissue-based and biochemical research, D-dimer antibody reagents are used to detect fibrin deposition and degradation within vascular and extravascular compartments. Localization of D-dimer-positive material provides insight into sites of active clot formation, fibrinolytic remodeling, and vascular injury. In cancer and inflammatory disease models, detection of cross-linked fibrin fragments can reveal interactions between coagulation pathways, immune cell infiltration, and tissue remodeling processes within the disease microenvironment.
The D-dimer antibody clone FGG/13043R is designed to recognize a neoantigenic determinant specific to the D-dimer fragment of cross-linked fibrin. Clone FGG/13043R does not detect native fibrinogen or uncleaved fibrin, supporting its use in research applications that require selective identification of fibrin degradation products. This monoclonal antibody enables precise investigation of coagulation dynamics, clot resolution, and fibrinolytic activity in physiological and pathological experimental systems. -
UniProt
- P02679
抗原
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