Recombinant Cytomegalovirus (CMV) (C-Term) 抗体
The 小鼠 单克隆 anti-Cytomegalovirus antibody (Clone rCMV-12688) (ABIN8093121) specifically detects Cytomegalovirus in IHC.
The antibody is reactive with Human Herpesvirus 5 (HHV-5) samples.
产品编号 ABIN8093121
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant Cytomegalovirus (CMV) (C-Term) 抗体 (ABIN8093121)
抗原
See all Cytomegalovirus (CMV) 抗体
Cytomegalovirus (CMV)
抗体类型
Recombinant Antibody
适用
Human Herpesvirus 5 (HHV-5)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (IHC)
克隆位点
RCMV-12688
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抗原表位
- C-Term
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原理
- Cytomegalovirus Antibody / UL83 / CMV matrix protein pp65
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免疫原
- Prokaryotic recombinant protein corresponding to a region at the C-terminal end of the cytomegalovirus pp65 molecule was used as the immunogen for the Phosphoprotein 65/UL83 antibody.
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亚型
- IgG1, kappa
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anti-Cytomegalovirus (CMV) antibody
CMV 适用: Cytomegalovirus (CMV) WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
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应用备注
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1. Optimal dilution of the Phosphoprotein 65/UL83 antibody should be determined by the researcher.
2. This Phosphoprotein 65/UL83 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存方法
- Phosphoprotein 65/UL83 antibody with sodium azide - store at 2 to 8oC
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- Cytomegalovirus (CMV)
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别名
- Cytomegalovirus
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物质类
- Virus
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背景
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Phosphoprotein 65 antibody recognizes UL83, also known as pp65, Human cytomegalovirus phosphoprotein 65, and Major Tegument Protein, a highly abundant structural component of Human cytomegalovirus virions. Phosphoprotein 65 Antibody targets one of the most immunodominant viral proteins expressed during active HCMV infection and packaged within the viral tegument layer. As the UL83 gene product, pp65 serves as both a structural virion protein and a regulator of host immune responses.
The UL83 gene encodes a lower matrix phosphoprotein that localizes primarily to the cytoplasm of infected cells, with early nuclear trafficking observed shortly after viral entry. As a tegument-associated protein, pp65 is delivered into host cells during infection and participates in modulation of innate immune signaling pathways, including interference with interferon-mediated antiviral responses. This activity contributes to viral immune evasion and supports efficient viral replication.
Phosphoprotein 65 is abundantly expressed during lytic infection and is widely used as a biomarker for active cytomegalovirus replication in research applications. Because of its strong immunogenicity, pp65 is a dominant antigen recognized by cytotoxic T lymphocytes in infected individuals. Its high expression levels and structural role in virion assembly make UL83 a preferred target for detection of HCMV-infected cells in experimental systems studying viral pathogenesis and host-virus interactions.
The UL83 protein is conserved across clinical HCMV isolates and remains central to investigations of transplant-associated CMV reactivation, congenital infection, and viral persistence in immunocompromised populations. Detection of pp65 expression assists in characterizing infection dynamics and evaluating antiviral strategies in laboratory models.
Clone rCMV/12688 is a recombinant mouse monoclonal antibody that recognizes UL83 / Phosphoprotein 65 and supports research applications focused on cytomegalovirus detection, viral replication studies, and immune response characterization. -
UniProt
- P06725
抗原
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