Recombinant Cytomegalovirus (CMV) (C-Term) 抗体
The 小鼠 单克隆 anti-Cytomegalovirus antibody is suitable to detect Cytomegalovirus in samples from Human Herpesvirus 5 (HHV-5). It has been validated for WB 和 IHC.
产品编号 ABIN8093117
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant Cytomegalovirus (CMV) (C-Term) 抗体 (ABIN8093117)
抗原
See all Cytomegalovirus (CMV) 抗体
Cytomegalovirus (CMV)
抗体类型
Recombinant Antibody
适用
Human Herpesvirus 5 (HHV-5)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunohistochemistry (IHC)
克隆位点
R6
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抗原表位
- C-Term
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原理
- Cytomegalovirus Antibody / HCMV pp65
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免疫原
- Prokaryotic recombinant protein corresponding to a region at the C-terminal end of the cytomegalovirus pp65 molecule was used as the immunogen for the HCMV pp65/UL83 antibody.
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亚型
- IgG1, kappa
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anti-Cytomegalovirus (CMV) antibody
CMV 适用: Cytomegalovirus (CMV) WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
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应用备注
- Optimal dilution of the HCMV pp65/UL83 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存方法
- HCMV pp65/UL83 antibody with sodium azide - store at 2 to 8oC
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- Cytomegalovirus (CMV)
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别名
- Cytomegalovirus
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物质类
- Virus
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背景
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HCMV pp65 antibody recognizes UL83, also known as Human cytomegalovirus phosphoprotein 65, a major tegument protein of Human cytomegalovirus that plays a central role in viral replication, immune modulation, and virion assembly. HCMV pp65 Antibody targets one of the most abundant structural proteins packaged within the viral tegument layer and is widely used as a marker of active HCMV infection in research settings.
UL83 encodes pp65, a highly immunogenic phosphoprotein that accumulates in the cytoplasm of infected cells during early and late stages of viral replication. Following infection, pp65 is delivered into host cells as part of the incoming virion and rapidly traffics to the nucleus before redistributing to the cytoplasm during viral assembly. As a major tegument protein, pp65 contributes to viral particle maturation and regulates host immune responses, including modulation of interferon signaling and antigen presentation pathways.
The UL83 gene is conserved among clinical isolates of HCMV and is frequently used as a diagnostic and research biomarker due to the protein’s abundance and strong immunogenicity. In infected tissues, pp65 is typically detected within cytoplasmic and perinuclear compartments of infected epithelial, endothelial, and fibroblast populations. Its high expression level makes it a preferred target for immunohistochemical and immunoblot-based detection of HCMV infection in experimental systems.
Because pp65 is a dominant antigen recognized by cytotoxic T lymphocytes, it plays a key role in shaping host adaptive immune responses during primary infection and viral reactivation. Altered pp65 expression patterns have been associated with viral latency, immune evasion strategies, and disease progression in immunocompromised individuals. These characteristics position UL83 as both a structural virion component and an immunomodulatory viral factor.
Clone r6 is a recombinant mouse monoclonal antibody that recognizes HCMV pp65 and supports research applications focused on viral detection, host-virus interaction studies, and characterization of cytomegalovirus infection models. -
UniProt
- P06725
抗原
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