Recombinant CEACAM1 抗体
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北京 101111
Quick Overview for Recombinant CEACAM1 抗体 (ABIN8093033)
抗原
See all CEACAM1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- CEACAM1 Antibody / Carcinoembryonic antigen-related cell adhesion molecule 1 (azide and preservative free)
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免疫原
- Prokaryotic recombinant protein corresponding to a 170 amino acid truncate (266 to 436aa) of the CD66a molecule was used as the immunogen for the CD66a Cell Adhesion Molecule/CEACAM1 antibody.
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亚型
- IgG1, kappa
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anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) antibody
CEACAM1 适用: 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 65-201) antibodyCEACAM1 适用: 人 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 7B9G3 unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) antibodyCEACAM1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-433) antibodyCEACAM1 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Monoclonal BLR090G unconjugated Recombinant Antibody
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 300-430) antibodyCEACAM1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) antibodyCEACAM1 适用: 人 FACS, IHC (fro), cELISA 宿主: 小鼠 Monoclonal GM-8G5 unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 65-201) antibodyCEACAM1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4F3B2 unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-143) antibodyCEACAM1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 36-145) antibodyCEACAM1 适用: 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 1-468) antibodyCEACAM1 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
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应用备注
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1. Optimal dilution of the CD66a Cell Adhesion Molecule/CEACAM1 antibody should be determined by the researcher.
2. This CD66a Cell Adhesion Molecule/CEACAM1 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- CD66a Cell Adhesion Molecule/CEACAM1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
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别名
- CEACAM1
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背景
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CD66a Cell Adhesion Molecule antibody, also known as CEACAM1 antibody, recognizes Carcinoembryonic antigen-related cell adhesion molecule 1, a type I transmembrane glycoprotein encoded by the CEACAM1 gene and commonly referred to as Biliary glycoprotein 1 and BGP-1. CD66a is a member of the carcinoembryonic antigen-related cell adhesion molecule family within the immunoglobulin superfamily and is primarily localized to the plasma membrane of epithelial and immune cells. It is expressed in liver, biliary epithelium, intestine, prostate, and mammary gland, as well as in subsets of activated T cells, B cells, and natural killer cells, supporting epithelial architecture and immune regulation.
CD66a Cell Adhesion Molecule antibody detects a protein composed of extracellular immunoglobulin-like domains, a single transmembrane region, and alternatively spliced cytoplasmic tails. Long cytoplasmic isoforms contain immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases and regulate downstream signaling pathways involved in proliferation, differentiation, and apoptosis. Short isoforms lack these motifs and exhibit altered regulatory capacity. In polarized epithelial tissues, CEACAM1 is enriched at apical and lateral membranes, where it contributes to maintenance of glandular structure and barrier integrity while coordinating adhesion-dependent signaling events.
Beyond its structural role, CD66a functions as an immune regulatory receptor. In lymphocytes, CEACAM1 can act as a co-inhibitory receptor influencing T cell activation, tolerance, and inflammatory responses, linking CD66a biology to immune checkpoint-like mechanisms. These functions position CEACAM1 as a relevant target in studies of immune homeostasis, tumor-immune interactions, and inflammatory signaling. In addition, several bacterial and viral pathogens utilize CEACAM family members as host receptors, underscoring the importance of this molecule in host-pathogen interaction research.
Altered expression of CEACAM1 has been reported in colorectal carcinoma, hepatocellular carcinoma, breast cancer, melanoma, and prostate cancer. In certain epithelial tumors, reduced expression correlates with decreased intercellular adhesion and increased invasiveness, while in other contexts elevated expression is associated with tumor progression and immune modulation. These context-dependent roles highlight the value of CD66a Cell Adhesion Molecule antibody for evaluating membrane protein expression patterns in both normal and disease-associated tissues.
This recombinant monoclonal antibody (clone r29H2) targets CEACAM1 protein in research applications. CD66a Cell Adhesion Molecule antibody supports investigation of adhesion molecule dynamics, isoform-specific signaling differences, and tumor-associated changes in CEACAM1 expression. -
UniProt
- P13688
抗原
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