Recombinant BCOR 抗体 (AA 100-400)
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北京 101111
Quick Overview for Recombinant BCOR 抗体 (AA 100-400) (ABIN8093013)
抗原
See all BCOR 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-400
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原理
- BCOR Antibody / BCL6 corepressor
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纯化方法
- Protein G affinity
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免疫原
- A recombinant fragment (around amino acids 100-400) of human BCOR protein (exact sequence is proprietary) was used as the immunogen for the Transcriptional Corepressor BCOR antibody.
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亚型
- IgG, kappa
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anti-BCL6 Co-Repressor (BCOR) (AA 1107-1137) antibody
BCOR 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19040 unconjugated
anti-BCL6 Co-Repressor (BCOR) (AA 1361-1460) antibodyBCOR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (N-Term) antibodyVerified BCOR 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (AA 1-1004) antibodyBCOR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (Internal Region) antibodyBCOR 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (AA 1553-1755) antibodyBCOR 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (AA 25-75) antibodyBCOR 适用: 人 IHC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (Internal Region) antibodyBCOR 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (AA 1705-1755) antibodyBCOR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-BCL6 Co-Repressor (BCOR) (Internal Region) antibodyBCOR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Optimal dilution of the Transcriptional Corepressor BCOR antibody should be determined by the researcher.
2. This Transcriptional Corepressor BCOR antibody is recombinantly produced by expression in human HEK293 cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Transcriptional Corepressor BCOR antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- BCOR (BCL6 Co-Repressor (BCOR))
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别名
- BCOR
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背景
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Transcriptional Corepressor BCOR antibody recognizes BCL-6 corepressor, a nuclear transcriptional regulator encoded by the BCOR gene. BCOR is a chromatin-associated protein that functions as a transcriptional corepressor and epigenetic modulator, primarily localizing to the nucleus where it participates in gene silencing complexes. As a component of noncanonical Polycomb repressive complex 1 variants, BCOR contributes to histone modification and stable transcriptional repression of lineage-specific genes.
BCOR interacts with sequence-specific transcription factors, including BCL6, to regulate gene expression programs involved in cell proliferation, differentiation, and apoptosis. Through recruitment of histone deacetylases and Polycomb group proteins, BCOR promotes chromatin condensation and transcriptional repression. These functions are critical during embryonic development, hematopoietic lineage commitment, and maintenance of cellular identity. BCOR is expressed in a range of tissues, with prominent nuclear expression in proliferative and differentiating cell populations.
The BCOR gene is located on the X chromosome and produces multiple transcript variants. Genetic alterations, mutations, and gene fusions involving BCOR have been reported in hematologic malignancies, certain sarcomas, and developmental disorders. Because of its role in epigenetic regulation and tumor biology, BCOR has become an important research target in oncology and developmental biology. Altered BCOR expression patterns may support tumor classification and molecular characterization in research settings.
This Transcriptional Corepressor BCOR antibody (clone BCOR/13087R) is suitable for detecting BCOR expression in research applications. The expected staining pattern is predominantly nuclear, consistent with its established role in transcriptional repression complexes. A Transcriptional Corepressor BCOR antibody is useful for studying chromatin remodeling, Polycomb-associated repression, hematologic malignancies, and developmental signaling pathways. -
UniProt
- Q6W2J9
抗原
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