Recombinant ADAR 抗体
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北京 101111
Quick Overview for Recombinant ADAR 抗体 (ABIN8093000)
抗原
See all ADAR 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ADAR Antibody / Adenosine deaminase acting on RNA
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纯化方法
- Purified
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免疫原
- A synthesized peptide derived from human Adenosine deaminase acting on RNA protein was used as the immunogen for the ADAR antibody.
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亚型
- IgG
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anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 1085-1223) antibody
ADAR 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4E2E4 unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 150-250) antibodyADAR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) antibodyKO Validated ADAR 适用: 人 WB, IF, ICC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 1-1226) antibodyADAR 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 1085-1223) antibodyADAR 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4E2B5 unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 1-1226) antibodyADAR 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 1-1152) antibodyADAR 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) antibodyKD Validated ADAR 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3090 unconjugated Recombinant Antibody
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 151-250) antibodyADAR 适用: 人 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific (ADAR) (AA 367-471) antibodyADAR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ADAR antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ADAR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ADAR (Adenosine Deaminase, RNA-Specific (ADAR))
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别名
- ADAR
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背景
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ADAR antibody targets Adenosine deaminase acting on RNA, an RNA-editing enzyme encoded by the ADAR gene that catalyzes the conversion of adenosine to inosine within double-stranded RNA substrates. This post-transcriptional modification alters RNA sequence information and can influence RNA stability, splicing, localization, and translation. Adenosine deaminase acting on RNA is a central regulator of RNA editing events that expand transcriptomic diversity and fine-tune gene expression across many cell types.
Adenosine deaminase acting on RNA contains conserved double-stranded RNA-binding domains at its N-terminus and a C-terminal deaminase catalytic domain. These domains enable selective binding to structured RNA regions and catalysis of deamination reactions. RNA editing mediated by ADAR can result in codon changes, modification of regulatory RNA elements, or alteration of microRNA processing. A short functional summary is that ADAR functions as a key enzymatic editor that modulates RNA sequence and function after transcription, thereby shaping protein diversity and regulatory RNA networks.
ADAR is broadly expressed in mammalian tissues, with particularly high expression reported in the brain, immune cells, and epithelial tissues. Subcellular localization is primarily nuclear, although cytoplasmic distribution has also been observed depending on cell type and activation state. Expression levels and activity of ADAR are dynamically regulated in response to developmental cues and cellular stress signals, including interferon signaling pathways, reflecting its role in innate immune regulation and RNA surveillance.
From a biological and disease relevance perspective, dysregulation of ADAR-mediated RNA editing has been linked to neurological disorders, autoimmune diseases, and cancer. Altered RNA editing patterns can disrupt normal gene function and contribute to aberrant signaling pathways. In immune contexts, ADAR activity helps distinguish self from non-self RNA, preventing inappropriate activation of antiviral responses. These diverse roles highlight the importance of precise control over ADAR expression and enzymatic activity in maintaining cellular homeostasis.
An ADAR antibody is a useful research tool for detecting adenosine deaminase acting on RNA expression and studying RNA editing mechanisms in cellular and tissue-based systems. Detection of ADAR supports investigations into RNA processing, transcriptome regulation, innate immune signaling, and disease-associated changes in RNA editing landscapes. This antibody targets adenosine deaminase acting on RNA for use in research applications focused on post-transcriptional gene regulation and RNA biology. -
UniProt
- P55265
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途径
- Protein targeting to Nucleus
抗原
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