Peptide Histidine-Methionine 抗体
The 小鼠 单克隆 anti-Peptide Histidine-Methionine antibody (Clone 3) (ABIN8065516) specifically detects Peptide Histidine-Methionine in ELISA 和 IHC.
The antibody is reactive with 人 samples.
产品编号 ABIN8065516
发货至:
中国
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Quick Overview for Peptide Histidine-Methionine 抗体 (ABIN8065516)
抗原
Peptide Histidine-Methionine (PHM)
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This Peptide Histidine-Methionine antibody is un-conjugated
应用范围
ELISA, Immunohistochemistry (IHC)
质量等级
Carrier-free
克隆位点
3
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原理
- Anti-Peptide Histidine Methionine Antibody
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特异性
- ABS 020-03 binds human PHM and cross-reacts with PACAP (approximately 12 % , incomplete, non-parallel inhibition). ABS 020-03 does not cross-react with GLP-1, GLP-2, VIP or glucagon.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Synthetic human peptide histidine-methionine
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亚型
- IgG2a, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- Peptide Histidine-Methionine (PHM)
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别名
- Peptide Histidine Methionine
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背景
- VIP, PHM27, VIP peptides, prepro-VIP,[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}., [Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}., [Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}.,VIP,Human peptide histidine-methionine (PHM) is a 27 amino acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations the effect of the peptides is to reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome.
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分子量
- 3 kDa
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基因ID
- 7432
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UniProt
- P01282
抗原
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