OXM 抗体
This 小鼠 单克隆 antibody specifically detects OXM in ELISA. It exhibits reactivity toward 人.
产品编号 ABIN8065514
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for OXM 抗体 (ABIN8065514)
抗原
See all OXM 抗体
OXM
(Oxyntomodulin (OXM))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This OXM antibody is un-conjugated
应用范围
ELISA
质量等级
Carrier-free
克隆位点
46
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原理
- Anti-Oxyntomodulin Antibody
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特异性
- ABS 064-46 is specific for C-terminus of human oxyntomodulin. Does not cross-react with glucagon. ABS 064-46 has a different epitope specificity compared to ABS 064-23 and ABS 059-20.
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预测反应
- Human,Mouse,and Rat
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纯化方法
- Protein A or Protein G purified
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免疫原
- Synthetic oxyntomodulin 31-37 coupled to carrier.
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- OXM (Oxyntomodulin (OXM))
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别名
- Oxyntomodulin
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背景
- GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Oxyntomodulin is a peptide hormone of 37 amino-acid residues (29-amino acid sequence of glucagon, with an 8-amino acid carboxy-terminal extension) produced by the L cells of the gut. It modulates gastric acid secretion from the oxyntic cells of the stomach, inhibits appetite and has glucose lowering effects. Oxyntomodulin is produced by cell-type-specific processing of proglucagon that forms as well glicentin, GLP-1 and GLP-2 in the L cells of the intestinal mucosa.
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分子量
- 20 kDa
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基因ID
- 2641
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UniProt
- P01275
抗原
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