HSPG2 抗体
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北京 101111
Quick Overview for HSPG2 抗体 (ABIN8065501)
抗原
See all HSPG2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Perlecan Antibody
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特异性
- CSI 001-74 is highly specific for perlecan. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin). Epitope is located in domain V
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预测反应
- Bovine,Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Bovine corneal endothelial cells
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亚型
- IgG1, kappa
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anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 4149-4391) antibody
HSPG2 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, 小鼠, Cow, 鱼, 猴, Pig IHC, IF, FACS 宿主: 大鼠 Monoclonal A7L6 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, Cow WB, IHC, ELISA, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal A71 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 524-701) antibodyHSPG2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (Domain 4) antibodyHSPG2 适用: 人, 小鼠, Cow, 大鼠 WB, IHC, IP, ICC, IHC (fro) 宿主: 大鼠 Monoclonal A7L6 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 25-134) antibodyHSPG2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
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别名
- Perlecan
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背景
- HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), perlecan proteoglycan,Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (PubMed:12435733, PubMed:15591058, PubMed:19789387). In muscle, it is essential for localizing acetylcholinesterase (AChE) at the neuromuscular junctions (NMJ), most probably acting as an adapter that links the acetylcholinesterase collagenic tail peptide (COLQ) to alpha-dystroglycan, and is therefore involved in the down-regulation of colinergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q05793, ECO:0000269|PubMed:12435733, ECO:0000269|PubMed:15591058, ECO:0000269|PubMed:19789387}., [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6., [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity.,HSPG2,Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodelling.
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分子量
- 400-450 kDa
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基因ID
- 3339
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UniProt
- P98160
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途径
- Glycosaminoglycan Metabolic Process, Lipid Metabolism
抗原
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