Fibronectin 抗体
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北京 101111
Quick Overview for Fibronectin 抗体 (ABIN8065460)
抗原
See all Fibronectin (FN) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Fibronectin Antibody
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特异性
- CSI 005-32 is highly specific for fibronectin. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, elastin, collagen, laminin). The antibody inhibits cell adhesion to fibronectin mediated by the heparin-binding domain. Epitope is located in the 40kD Hep II heparin-binding domain.
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预测反应
- Bovine,Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Bovine corneal endothelial cells
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亚型
- IgG1, kappa
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anti-Fibronectin (FN) (AA 1201-1300) antibody
FN 适用: 小鼠 WB, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 2117-2236) antibodyFN 适用: 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 355-558) antibodyFN 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 313-607) antibodyFN 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (C-Term) antibodyFN 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 1998-2106) antibodyFN 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 2240-2280) antibodyFN 适用: 人 WB 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Fibronectin (FN) (AA 510-689) antibodyFN 适用: 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (FN) (AA 355-558) antibodyFN 适用: 大鼠 WB 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Fibronectin (FN) (AA 2206-2337) antibodyFN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- Fibronectin (FN)
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别名
- Fibronectin
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背景
- FN1, fibronectin 1,Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). {ECO:0000250|UniProtKB:P02751, ECO:0000250|UniProtKB:P11276}., [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000250|UniProtKB:P02751}., Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. {ECO:0000250|UniProtKB:P11276}.,FN1,Fibronectin is an adhesive glycoprotein with a molecular mass of 440 kDa. It is believed to be important for the formation of a provisional matrix that promotes cell adhesion and migration during wound healing. Its age-dependent increase in plasma and tissues may be accompanied in pathological states, especially in tumor growth, by its proteolytic breakdown by a number of neutral proteases. It has also shown that several of its proteolytic breakdown products exhibit unexpected and mostly harmful biological activities. (1)
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分子量
- 440 kDa glycoprotein dimer, with monomers running at 260 on SDS-PAGE
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基因ID
- 280794
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UniProt
- P07589
抗原
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