COL3 抗体
Our Local Distributor
北京 101111
Quick Overview for COL3 抗体 (ABIN8065429)
抗原
See all COL3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
原理
- Anti-Type III Collagen Antibody
-
特异性
- CSI 007-01 is highly specific for type III collagen. It has been shown to have no cross-ractivity with type I and V collagens by ELISA and immunoblotting. There is no evidence for cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). Epitope is located approximately 100nm from the N-terminal of the molecule.
-
预测反应
- Canine,Human,Kangaroo,and Rat
-
纯化方法
- Protein A or Protein G purified
-
免疫原
- Acid-digested pepsin soluble human type III collagen
-
亚型
- IgG1, kappa
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- 2-8°C without exposure to light
-
有效期
- 24 months
-
-
- COL3 (Collagen, Type III (COL3))
-
别名
- Type III Collagen
-
背景
- COL3A1, EDS4A, EDSVASC, PMGEDSV, collagen alpha-1(III) chain, Ehlers-Danlos syndrome type IV, autosomal dominant, alpha-1 type III collagen, alpha1 (III) collagen, collagen, fetal, collagen, type III, alpha 1,Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.,COL3A1,Type III collagen is present in the walls of arteries, intestines and the uterus, where it strenghtens the connective tissue. Patients with defects in the type III collagen (ex. Ehlers-Danlos syndrome) are at risk of rupture of major arteries or the intestine.
-
分子量
- 139 kDa
-
基因ID
- 1281
-
UniProt
- P02461
抗原
-