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COL3 抗体

The 小鼠 单克隆 anti-COL3 antibody (Clone 1E7-D7-Col3) (ABIN8065429) specifically detects COL3 in WB, IHC 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN8065429
发货至: 中国
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Quick Overview for COL3 抗体 (ABIN8065429)

抗原

See all COL3 抗体
COL3 (Collagen, Type III (COL3))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This COL3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA

质量等级

Carrier-free

克隆位点

1E7-D7-Col3
  • 原理

    Anti-Type III Collagen Antibody

    特异性

    CSI 007-01 is highly specific for type III collagen. It has been shown to have no cross-ractivity with type I and V collagens by ELISA and immunoblotting. There is no evidence for cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). Epitope is located approximately 100nm from the N-terminal of the molecule.

    预测反应

    Canine,Human,Kangaroo,and Rat

    纯化方法

    Protein A or Protein G purified

    免疫原

    Acid-digested pepsin soluble human type III collagen

    亚型

    IgG1, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2-8°C without exposure to light

    有效期

    24 months
  • 抗原

    COL3 (Collagen, Type III (COL3))

    别名

    Type III Collagen

    背景

    COL3A1, EDS4A, EDSVASC, PMGEDSV, collagen alpha-1(III) chain, Ehlers-Danlos syndrome type IV, autosomal dominant, alpha-1 type III collagen, alpha1 (III) collagen, collagen, fetal, collagen, type III, alpha 1,Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.,COL3A1,Type III collagen is present in the walls of arteries, intestines and the uterus, where it strenghtens the connective tissue. Patients with defects in the type III collagen (ex. Ehlers-Danlos syndrome) are at risk of rupture of major arteries or the intestine.

    分子量

    139 kDa

    基因ID

    1281

    UniProt

    P02461
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