Adrenomedullin 抗体
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Quick Overview for Adrenomedullin 抗体 (ABIN8065421)
抗原
See all Adrenomedullin (ADM) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Adrenomedullin Antibody
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特异性
- ABS 027-01 binds human adrenomedullin and shows no cross-reaction with CGRP. The epitope of ABS 027-01 lies within residues 22-52.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Synthetic human adrenomedullin 1-52
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亚型
- IgG1, kappa
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anti-Adrenomedullin (ADM) (AA 22-147) antibody
ADM 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenomedullin (ADM) (AA 24-171) antibodyADM 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenomedullin (ADM) (AA 22-147) antibodyADM 适用: 人 WB 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Adrenomedullin (ADM) (AA 45-92) antibodyADM 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenomedullin (ADM) (AA 122-140) antibodyADM 适用: 人 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adrenomedullin (ADM) (AA 50-150) antibodyADM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenomedullin (ADM) (Internal Region) antibodyADM 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- Adrenomedullin (ADM)
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别名
- Adrenomedullin
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物质类
- Hormone
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背景
- ADM, AM, PAMP, pro-adrenomedullin, preproadrenomedullin, proadrenomedullin N-20 terminal peptide,Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. {ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Adrenomedullin]: Peptide hormone that act as potent hypotensive and vasodilatator agents (PubMed:8387282). ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex (PubMed:32296767, PubMed:9620797). {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Proadrenomedullin N-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563). {ECO:0000269|PubMed:15823563, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}., [Proadrenomedullin 9-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875). {ECO:0000269|PubMed:15823563, ECO:0000269|PubMed:34789875, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}.,ADM,Human adrenomedullin is a 52 amino acid peptide (MW 6029) with the physiological effect of lowering blood pressure through vasodilatation, an effect it shares with calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). In addition adrenomedullin has other cardiovascular effects including growth and development of both cardiovascular tissues and bone, and has effects in the central nervous system connected with the regulation of fluid balance.
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分子量
- 21 kDa (preproadrenomedullin), 6 kDa (mature peptide)
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基因ID
- 133
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UniProt
- P35318
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途径
- Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation
抗原
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