PATZ1 抗体 (AA 145-680) (HRP)
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Quick Overview for PATZ1 抗体 (AA 145-680) (HRP) (ABIN8055224)
抗原
See all PATZ1 (ZNF278) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 145-680
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原理
- Anti-PATZ1 Antibody HRP Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PATZ1 recombinant protein (Position: M145-Q680). Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
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别名
- PATZ1
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背景
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Background: POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Gene Full Name: POZ/BTB and AT hook containing zinc finger 1
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基因ID
- 23598
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UniProt
- Q9HBE1
抗原
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