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PROC 抗体 (C-Term) (HRP)

The 兔 多克隆 anti-PROC antibody is suitable to detect PROC in samples from 人. It has been validated for WB, IHC 和 ELISA.
产品编号 ABIN8053770
发货至: 中国
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Quick Overview for PROC 抗体 (C-Term) (HRP) (ABIN8053770)

抗原

See all PROC 抗体
PROC (Vitamin K-dependent protein C (PROC))

适用

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宿主

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克隆类型

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多克隆

标记

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This PROC antibody is conjugated to HRP

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
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    C-Term

    原理

    Anti-Protein C/PROC Antibody HRP Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

    亚型

    IgG
  • 应用备注

    Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

    有效期

    12 months
  • 抗原

    PROC (Vitamin K-dependent protein C (PROC))

    别名

    PROC

    背景

    Background: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.

    Gene Full Name: protein C, inactivator of coagulation factors Va and VIIIa

    Sequence Similarities: Belongs to the peptidase S1 family.

    基因ID

    5624

    UniProt

    P04070
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