Tumor Protein p73 抗体 (AA 1-198)
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Quick Overview for Tumor Protein p73 抗体 (AA 1-198) (ABIN8051676)
抗原
See all Tumor Protein p73 (TP73) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1-198
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原理
- Anti-p73/TP73 Antibody
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.
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产品特性
- Anti-p73/TP73 Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.
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亚型
- IgG
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应用备注
- Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, RatWestern blot, 0.1-0.5 μg/mL, Human
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
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别名
- TP73
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背景
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Background: p73, also known as tumor protein 73 (TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.
Gene Full Name: tumor protein p73
Sequence Similarities: Belongs to the p53 family.
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分子量
- 73 kDa
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基因ID
- 7161
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UniProt
- O15350
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途径
- Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus
抗原
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