RPH3AL 抗体 (AA 25-130) (HRP)
Quick Overview for RPH3AL 抗体 (AA 25-130) (HRP) (ABIN755062)
抗原
See all RPH3AL 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 25-130
-
交叉反应
- 小鼠
-
预测反应
- Human,Rat,Dog,Cow,Chicken,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human RPH3AL
-
亚型
- IgG
-
-
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibody
RPH3AL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibodyRPH3AL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 1-315) antibodyRPH3AL 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 208-237), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24121 unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 211-241), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
-
别名
- RPH3AL
-
背景
-
Synonyms: Noc2, Rab effector Noc2, Rabphilin 3A-like without C2 domains, Rabphilin 3A-like, Rabphilin-3A-like protein, RPH3AL, RPH3L_HUMAN, No C2 domains protein, Gm1753.
Background: Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
-
基因ID
- 9501
-
途径
- Carbohydrate Homeostasis, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
-
