RPH3AL 抗体 (AA 25-130)
Quick Overview for RPH3AL 抗体 (AA 25-130) (ABIN755053)
抗原
See all RPH3AL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-130
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human RPH3AL
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亚型
- IgG
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anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibody
RPH3AL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibodyRPH3AL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 1-315) antibodyRPH3AL 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 208-237), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24121 unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 211-241), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
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别名
- RPH3AL
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背景
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Synonyms: Noc2, Rab effector Noc2, Rabphilin 3A-like without C2 domains, Rabphilin 3A-like, Rabphilin-3A-like protein, RPH3AL, RPH3L_HUMAN, No C2 domains protein, Gm1753.
Background: Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
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基因ID
- 9501
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途径
- Carbohydrate Homeostasis, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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