TYMS 抗体 (AA 1-313) (Fluoro488)
Our Local Distributor
北京 101111
Quick Overview for TYMS 抗体 (AA 1-313) (Fluoro488) (ABIN8046524)
抗原
See all TYMS 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-313
-
原理
- Anti-Thymidylate Synthase/TYMS Antibody Fluoro488 Conjugated
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human Thymidylate Synthase/TYMS recombinant protein (Position: M1-V313).
-
亚型
- IgG
-
-
-
-
应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- TYMS (Thymidylate Synthetase (TYMS))
-
别名
- TYMS
-
背景
-
Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.
Gene Full Name: thymidylate synthetase
-
基因ID
- 7298
-
UniProt
- P04818
-
途径
- Mitotic G1-G1/S Phases
抗原
-