SWAP70 抗体 (AA 161-292) (FITC)
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北京 101111
Quick Overview for SWAP70 抗体 (AA 161-292) (FITC) (ABIN8044014)
抗原
See all SWAP70 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-292
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原理
- Anti-SWAP70 Antibody FITC Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SWAP70 recombinant protein (Position: H161-K292).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))
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别名
- SWAP70
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背景
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Background: SWAP70 (Switch-associated protein 70) is a 67-70 kDa intracellular protein that bears limited resemblance to members of the Dbl-family of GEFs for small Rho GTPases. It is expressed in mast cells, dendritic cells and B cells. In mast cells, it promotes the release of anaphylactic mediators, in dendritic cells, it regulates the appearance of MHC II, and in B cells, it forms a nuclear complex that initiates immunoglobulin class switching. Human SWAP70 is 585 amino acids (aa) in length. It contains one plextrin homology (PH) domain (aa 213-304) plus a coiled-coil region (aa 316-539). There are three potential splice variants. One contains an alternative start site at Met70, another shows a deletion of aa 81-138, and a third possesses a 38 aa substitution for aa 453-585. Over aa 386-585, human SWAP70 shares 96 % aa identity with mouse SWAP70.
Gene Full Name: switching B cell complex subunit SWAP70
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基因ID
- 23075
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UniProt
- Q9UH65
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途径
- Production of Molecular Mediator of Immune Response
抗原
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