Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 594-1909) 抗体
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Quick Overview for Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 594-1909) 抗体 (ABIN8041407)
抗原
See all Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 594-1909
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原理
- Anti-SPTBN2 Antibody
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-SPTBN2 Antibody. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SPTBN2 recombinant protein (Position: A594-K1909).
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亚型
- IgG
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应用备注
- Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/mL, -
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. -
有效期
- 12 months
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- Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)
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别名
- SPTBN2
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背景
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Background: Spectrin beta chain, brain 2 is a protein that in humans is encoded by the SPTBN2 gene. Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
Gene Full Name: spectrin beta, non-erythrocytic 2
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分子量
- 271 kDa
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基因ID
- 6712
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UniProt
- O15020
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途径
- Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis
抗原
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