SMAD7 抗体 (AA 88-135) (HRP)
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Quick Overview for SMAD7 抗体 (AA 88-135) (HRP) (ABIN8038219)
抗原
See all SMAD7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 88-135
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原理
- Anti-MADH7/SMAD7 Antibody HRP Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MADH7/SMAD7 recombinant protein (Position: A88-R135).
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
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别名
- SMAD7
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背景
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Background: Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Gene Full Name: SMAD family member 7
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基因ID
- 4092
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UniProt
- O15105
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途径
- Interferon-gamma Pathway, Cell-Cell Junction Organization
抗原
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