SERPINH1 抗体 (AA 247-418) (Fluoro488)
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北京 101111
Quick Overview for SERPINH1 抗体 (AA 247-418) (Fluoro488) (ABIN8036283)
抗原
See all SERPINH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 247-418
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原理
- Anti-Hsp47/SERPINH1 Antibody Fluoro488 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse,rat Hsp47.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Hsp47 recombinant protein (Position: D247-L418). Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp47.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- SERPINH1 (Serpin Family H Member 1 (SERPINH1))
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别名
- SERPINH1
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背景
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Background: Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen, thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.
Gene Full Name: serpin family H member 1
Sequence Similarities: Belongs to the serpin family.
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基因ID
- 871
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UniProt
- P50454
抗原
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