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ECT2 抗体 (AA 781-883)

Name: ECT2 抗体 (AA 781-883)
SKU: ABIN753853
Availability: OutOfStock

This anti-ECT2 antibody is a 兔多克隆 antibody detecting ECT2 in WB, ELISA, IF (cc), IF (p), IHC (p) 和 IHC (fro). Suitable for 人和大鼠. This Primary Antibody has been cited in 2+ publications.

Formalin-fixed and paraffin embedded human lung labeled with Anti-ECT2 Polyclonal Antibody, Unconjugated at 1:300 followed by conjugation to the secondary antibody and DAB staining. (ECT2 抗体 (AA 781-883))

IHC (p)

1 image

(2 references)

产品编号 ABIN753853

发货至: 中国

Datasheet as PDF

Quick Overview for ECT2 抗体 (AA 781-883) (ABIN753853)

抗原

See all ECT2 抗体

ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

适用

人, 大鼠

宿主

兔

克隆类型

多克隆

标记

This ECT2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product ECT2 Primary Antibody

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AA 781-883

交叉反应

人, 大鼠

预测反应

Mouse,Dog,Cow,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human ECT2

亚型

IgG
anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 283-453) antibody
ECT2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (N-Term) antibody
Verified ECT2 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 453-647) antibody
ECT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 166-348) antibody
ECT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 46-145) antibody
ECT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D4 unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) antibody
ECT2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 200-460) antibody
ECT2 适用: 人 WB 宿主: 小鼠 Monoclonal 1691CT516-3-3 unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 551-600) antibody
ECT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, 斑马鱼, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 580-629) antibody
ECT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated

anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (N-Term) antibody
ECT2 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Wang, Yan, Liu: "Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients." in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Vol. 18, Issue 7, pp. 735-42, (2016) (PubMed).

Guo, Chen, Du, Zhu, Lai, Dong, Wu, Lin, Liu, Huang: "Elevated levels of epithelial cell transforming sequence 2 predicts poor prognosis for prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 34, Issue 1, pp. 13, (2016) (PubMed).
抗原

ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

别名

ECT2

背景

Synonyms: ARHGEF31, Protein ECT2, Epithelial cell-transforming sequence 2 oncogene, ECT2
Background: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

基因ID

1894

UniProt

Q9H8V3

途径

Neurotrophin Signaling Pathway, Cell-Cell Junction Organization