REST 抗体 (AA 110-1097) (Biotin)
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Quick Overview for REST 抗体 (AA 110-1097) (Biotin) (ABIN8030837)
抗原
See all REST 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 110-1097
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原理
- Anti-REST Antibody Biotin Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human REST shares 62.9%,59.6% amino acid (aa) sequence identity with mouse,rat REST,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human REST recombinant protein (Position: E110-E1097). Human REST shares 62.9% and 59.6% amino acid (aa) sequence identity with mouse and rat REST, respectively.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- REST (RE1-Silencing Transcription Factor (REST))
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别名
- REST
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背景
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Background: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.
Gene Full Name: RE1 silencing transcription factor
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基因ID
- 5978
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UniProt
- Q13127
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途径
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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