RAP1GAP 抗体 (AA 11-661) (PE)
Our Local Distributor
北京 101111
Quick Overview for RAP1GAP 抗体 (AA 11-661) (PE) (ABIN8030478)
抗原
See all RAP1GAP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 11-661
-
原理
- Anti-RAP1GAP Antibody PE Conjugated
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RAP1GAP recombinant protein (Position: D11-L661).
-
亚型
- IgG
-
-
-
-
应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))
-
别名
- RAP1GAP
-
背景
-
Background: Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene. This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Gene Full Name: RAP1 GTPase activating protein
-
基因ID
- 5909
-
UniProt
- P47736
抗原
-