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RAN 抗体 (AA 2-216)

Name: RAN 抗体 (AA 2-216)
SKU: ABIN8030414
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects RAN in WB, FACS, IF 和 ICC. It exhibits reactivity toward 人, 小鼠和大鼠.

产品编号 ABIN8030414

发货至: 中国

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Quick Overview for RAN 抗体 (AA 2-216) (ABIN8030414)

抗原

See all RAN 抗体

RAN (RAN, Member RAS Oncogene Family (RAN))

适用

人, 小鼠, 大鼠

宿主

小鼠

克隆类型

单克隆

标记

This RAN antibody is un-conjugated

应用范围

Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

质量等级

Carrier-free

克隆位点

5D5

Discover our top product RAN Primary Antibody

抗原表位
24

15

15

8

6

4

4

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 2-216

原理

Anti-Ran Antibody (monoclonal, 5D5)

特异性

No cross reactivity with other proteins.

交叉反应（详细）

No cross-reactivity with other proteins.

预测反应

coli-derived human Ran recombinant protein (Position: A2-L216). Human Ran shares 100% amino acid (aa) sequence identity with both mouse,rat Ran.

产品特性

Anti-Ran Antibody.(monoclonal, 5D5)-1. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

E. coli-derived human Ran recombinant protein (Position: A2-L216). Human Ran shares 100% amino acid (aa) sequence identity with both mouse and rat Ran.

亚型

IgG2b
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8D1A6 unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (N-Term) antibody
Verified RAN 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39), (N-Term) antibody
RAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20229 unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 2-216) antibody
RAN 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-179) antibody
RAN 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 166-216) antibody
RAN 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39) antibody
RAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 197-210) antibody
Verified RAN 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140) antibody
RAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20230 unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL Immunocytochemistry/Immunofluorescence, 2 μg/mL Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

RAN (RAN, Member RAS Oncogene Family (RAN))

别名

RAN

背景

Background: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Gene Full Name: RAN, member RAS oncogene family

分子量

24 kDa

基因ID

5901

UniProt

P62826

途径

Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus