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RAD17 抗体 (AA 1-267) (FITC)

The FITC-conjugated 兔 多克隆 anti-RAD17 antibody (ABIN8030056) specifically detects RAD17 in FACS. The antibody is reactive with 小鼠 和 大鼠 samples.
产品编号 ABIN8030056
发货至: 中国
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Quick Overview for RAD17 抗体 (AA 1-267) (FITC) (ABIN8030056)

抗原

See all RAD17 抗体
RAD17

适用

  • 113
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小鼠, 大鼠

宿主

  • 122
  • 4
  • 3

克隆类型

  • 114
  • 14
多克隆

标记

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This RAD17 antibody is conjugated to FITC

应用范围

  • 73
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  • 14
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  • 6
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  • 1
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Flow Cytometry (FACS)
  • 抗原表位

    • 21
    • 15
    • 13
    • 12
    • 10
    • 7
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    • 2
    • 2
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    • 2
    • 1
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    AA 1-267

    原理

    Anti-Rad17 Antibody FITC Conjugated

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived mouse Rad17 recombinant protein (Position: M1-Q267).

    亚型

    IgG
  • 应用备注

    Flow Cytometry, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

    有效期

    12 months
  • 抗原

    RAD17

    别名

    Rad17

    背景

    Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

    Gene Full Name: RAD17 checkpoint clamp loader component

    基因ID

    19356

    UniProt

    Q6NXW6
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