PPM1F 抗体 (AA 17-454) (HRP)
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Quick Overview for PPM1F 抗体 (AA 17-454) (HRP) (ABIN8027982)
抗原
See all PPM1F 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 17-454
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原理
- Anti-PPM1F Antibody HRP Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PPM1F recombinant protein (Position: E17-S454).
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))
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别名
- PPM1F
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背景
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Background: Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1F
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基因ID
- 9647
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UniProt
- P49593
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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