PDIA3 抗体 (C-Term) (FITC)
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Quick Overview for PDIA3 抗体 (C-Term) (FITC) (ABIN8027217)
抗原
See all PDIA3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Anti-ERp57 Antibody (monoclonal, 7E5) FITC Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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预测反应
- different from the related mouse,rat sequences by two amino acids.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human ERp57, different from the related mouse and rat sequences by two amino acids.
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亚型
- IgG1
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
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别名
- PDIA3
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背景
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Background: PDIA3 (Protein disulfide isomerase family A, member 3), also called GRP58, Erp57 or ER60, is an isomerase enzyme. It is mapped on 15q15.3. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex, which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface. This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase, however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
Gene Full Name: protein disulfide isomerase family A member 3
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基因ID
- 2923
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UniProt
- P30101
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途径
- Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis
抗原
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