PRAME 抗体 (AA 21-509)
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北京 101111
Quick Overview for PRAME 抗体 (AA 21-509) (ABIN8025094)
抗原
See all PRAME 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 21-509
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原理
- Anti-PRAME Antibody
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-PRAME.Antibody-2. Tested in ELISA, WB applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PRAME recombinant protein (Position: T21-N509).
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亚型
- IgG
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应用备注
- Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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别名
- PRAME
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背景
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Background: Melanoma antigen preferentially expressed in tumors is a protein that in humans is encoded by the PRAME gene. It is mapped to 22q11.22. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Gene Full Name: PRAME nuclear receptor transcriptional regulator
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分子量
- 58 kDa
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基因ID
- 23532
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UniProt
- P78395
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途径
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
抗原
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