PER2 抗体 (AA 13-330) (Fluoro550)
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Quick Overview for PER2 抗体 (AA 13-330) (Fluoro550) (ABIN8020497)
抗原
See all PER2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 13-330
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原理
- Anti-PER2 Antibody Fluoro550 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human PER2 shares 84%,83% amino acid (aa) sequence identity with mouse,rat PER2,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- PER2 (Period Circadian Protein 2 (PER2))
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别名
- PER2
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背景
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Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.
Gene Full Name: period circadian regulator 2
Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.
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基因ID
- 8864
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UniProt
- O15055
抗原
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