PELI2 抗体 (AA 118-420) (HRP)
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Quick Overview for PELI2 抗体 (AA 118-420) (HRP) (ABIN8020023)
抗原
See all PELI2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 118-420
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原理
- Anti-PELI2 Antibody HRP Conjugated
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交叉反应 （详细）
- No cross reactivity with other proteins.
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预测反应
- Human PELI2 shares 97.4% amino acid (aa) sequence identity with mouse?PELI2.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PELI2 recombinant protein (Position: D118-D420). Human PELI2 shares 97.4% amino acid (aa) sequence identity with mouse?PELI2.
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亚型
- IgG
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anti-Pellino Homolog 2 (Drosophila) (PELI2) (AA 1-420) antibody
PELI2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Pellino Homolog 2 (Drosophila) (PELI2) (N-Term) antibodyPELI2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))
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别名
- PELI2
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背景
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Background: Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Gene Full Name: pellino E3 ubiquitin protein ligase family member 2
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基因ID
- 57161
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UniProt
- Q9HAT8
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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