Oncostatin M Receptor 抗体 (AA 673-968) (Fluoro647)
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Quick Overview for Oncostatin M Receptor 抗体 (AA 673-968) (Fluoro647) (ABIN8018112)
抗原
See all Oncostatin M Receptor (OSMR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 673-968
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原理
- Anti-Osmr Antibody Fluoro647 Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Mouse Osmr shares 57.7%,86.9% amino acid (aa) sequence identity with human,rat Osmr,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968). Mouse Osmr shares 57.7% and 86.9% amino acid (aa) sequence identity with human and rat Osmr, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- Oncostatin M Receptor (OSMR)
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别名
- Osmr
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背景
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Background: Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. Mosley et al. (1996) used degenerate PCR to clone a novel hematopoietin receptor which they called the oncostatin M-specific receptor beta subunit (OSMR-beta). Sequencing revealed that this gene encodes a 979-amino acid protein containing characteristic motifs of the hematopoietin receptor family.
Gene Full Name: oncostatin M receptor
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基因ID
- 18414
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UniProt
- O70458
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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