NCOA2 抗体 (AA 297-1071) (Fluoro594)
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北京 101111
Quick Overview for NCOA2 抗体 (AA 297-1071) (Fluoro594) (ABIN8016797)
抗原
See all NCOA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 297-1071
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原理
- Anti-NCOA2 Antibody Fluoro594 Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human NCOA2 shares 93.4%,90.8% amino acid (aa) sequence identity with mouse,rat NCOA2,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071). Human NCOA2 shares 93.4% and 90.8% amino acid (aa) sequence identity with mouse and rat NCOA2, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))
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别名
- NCOA2
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背景
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Background: The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
Gene Full Name: nuclear receptor coactivator 2
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基因ID
- 10499
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UniProt
- Q15596
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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