N4BP1 抗体 (AA 1-885) (PE)
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北京 101111
Quick Overview for N4BP1 抗体 (AA 1-885) (PE) (ABIN8014127)
抗原
See all N4BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-885
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原理
- Anti-N4BP1 Antibody PE Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human N4BP1 recombinant protein (Position: M1-K885).
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亚型
- IgG
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anti-NEDD4 Binding Protein 1 (N4BP1) antibody
N4BP1 适用: 小鼠 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB120 unconjugated Recombinant Antibody
anti-NEDD4 Binding Protein 1 (N4BP1) (Internal Region) antibodyN4BP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NEDD4 Binding Protein 1 (N4BP1) (AA 190-590) antibodyN4BP1 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NEDD4 Binding Protein 1 (N4BP1) (AA 1-896) antibodyN4BP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NEDD4 Binding Protein 1 (N4BP1) (AA 250-300) antibodyN4BP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-NEDD4 Binding Protein 1 (N4BP1) antibodyN4BP1 适用: 小鼠, 大鼠 WB 宿主: 兔 Monoclonal 28N99 unconjugated
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- N4BP1 (NEDD4 Binding Protein 1 (N4BP1))
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别名
- N4BP1
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背景
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Background: Nedd4-binding partner-1 (N4BP1) has been identified as a protein interactor and a substrate of the homologous to E6AP C terminus (HECT) domain-containing E3 ubiquitin-protein ligase (E3), Nedd4. Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity. We show that N4BP1 association with the second WW domain (WW2) of Itch interferes with E3 binding to its substrates. In particular, we found that N4BP1 and p73α, a target of Itch-mediated ubiquitin/proteasome proteolysis, share the same binding site. By competing with p73α for binding to the WW2 domain, N4BP1 reduces the ability of Itch to recruit and ubiquitylate p73α and inhibits Itch autoubiquitylation activity both in in vitro and in vivo ubiquitylation assays.
Gene Full Name: NEDD4 binding protein 1
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基因ID
- 9683
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UniProt
- O75113
抗原
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