MLKL 抗体 (AA 210-464)
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北京 101111
Quick Overview for MLKL 抗体 (AA 210-464) (ABIN8011465)
抗原
See all MLKL 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 210-464
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原理
- Anti-MLKL Antibody
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交叉反应 （详细）
- No cross reactivity with other proteins.
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预测反应
- Human MLKL shares 69.7% amino acid (aa) sequence identity with mouse MLKL.
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产品特性
- Anti-MLKL Antibody. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MLKL recombinant protein (Position: R210-K464). Human MLKL shares 69.7% amino acid (aa) sequence identity with mouse MLKL.
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亚型
- IgG
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anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 371-471) antibody
MLKL 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (Internal Region) antibodyMLKL 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 1-471) antibodyMLKL 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyKD Validated MLKL 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2935 unconjugated Recombinant Antibody
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyKD Validated MLKL 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4615 unconjugated Recombinant Antibody
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyKD Validated MLKL 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4620 unconjugated Recombinant Antibody
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyKD Validated MLKL 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2895 unconjugated Recombinant Antibody
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 444-472) antibodyMLKL 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (pSer358) antibodyMLKL 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal 6E3 unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 371-472) antibodyMLKL 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B2 unconjugated
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应用备注
- Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/mL, -
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. -
有效期
- 12 months
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- MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
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别名
- MLKL
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背景
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Background: Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Gene Full Name: mixed lineage kinase domain like pseudokinase
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分子量
- 50 kDa
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基因ID
- 197259
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UniProt
- Q8NB16
抗原
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