Melanophilin 抗体 (AA 61-523) (HRP)
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Quick Overview for Melanophilin 抗体 (AA 61-523) (HRP) (ABIN8008963)
抗原
See all Melanophilin (MLPH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 61-523
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原理
- Anti-MLPH Antibody HRP Conjugated
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预测反应
- Human Melanophilin,MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin,MLPH.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Melanophilin/MLPH recombinant protein (Position: E61-L523). Human Melanophilin/MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin/MLPH.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- Melanophilin (MLPH)
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别名
- MLPH
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背景
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Background: Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Full Name: melanophilin
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基因ID
- 79083
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UniProt
- Q9BV36
抗原
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