LDLR 抗体 (AA 35-843) (PE)
Our Local Distributor
北京 101111
Quick Overview for LDLR 抗体 (AA 35-843) (PE) (ABIN8006544)
抗原
See all LDLR 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 35-843
-
原理
- Anti-LDL Receptor/LDLR Antibody PE Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human LDL Receptor/LDLR recombinant protein (Position: Q35-D843).
-
亚型
- IgG
-
-
-
-
应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- LDLR (Low Density Lipoprotein Receptor (LDLR))
-
别名
- LDLR
-
背景
-
Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Gene Full Name: low density lipoprotein receptor
-
基因ID
- 3949
-
UniProt
- P01130
-
途径
- Hepatitis C, Lipid Metabolism
抗原
-